Cortical Clefts and Cortical Bumps:
A Continuous Spectrum
Published: July 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/.8179
Asthik Biswas, Farha Furruqh, Suresh Thirunavukarasu, Ravichandran Vivekandan
1. Senior Resident, Department of Radiology, St John’s Medical College Hospital, Bengaluru, Karnataka, India.
2. Senior Resident, Department of Radiology, St John’s Medical College Hospital, Bengaluru, Karnataka, India.
3. Specialist Grade II, Department of Neurology, Indira Gandhi Government General Hospital and Post Graduate Institute, Puducherry, India.
4. Specialist Grade I, Indira Gandhi Government General Hospital and Post Graduate Institute, Puducherry, India.
Correspondence
Dr. Asthik Biswas,
78-Omkar Nagar, Arekere Mico Layout, Bannerghatta Road, Bengaluru-560076, Karnataka, India.
E-mail: asthikbiswas@gmail.com
Cortical ‘clefts’ (schizencephaly) and cortical ‘bumps’ (polymicrogyria) are malformations arising due to defects in postmigrational development of neurons. They are frequently encountered together, with schizencephalic clefts being lined by polymicrogyria. We present the case of an eight-year-old boy who presented with seizures. Imaging revealed closed lip schizencephaly, polymicrogyria and a deep ‘incomplete’ cleft lined by polymicrogyria not communicating with the lateral ventricle. We speculate that hypoperfusion or ischaemic cortical injury during neuronal development may lead to a spectrum of malformations ranging from polymicrogyria to incomplete cortical clefts to schizencephaly.
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